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Advanced Prostate Cancer

Prostate cancer occurs when cancerous cells develop in the prostate gland, a walnut-shaped organ located below the bladder in males which aids in the production of semen. Cancer which has advanced to a late stage and spread beyond the prostate, to lymph nodes or other areas of the body, is called metastatic prostate cancer.

There have been a number of major medical breakthroughs in recent years that have allowed physicians to help extend the survival of patients with metastatic prostate cancer for a significant period of time.  Skyline Urology physicians will work with you to manage your advanced prostate cancer. There are a number of newer treatments that can help, to control its further spread or to minimize the side effects and symptoms of the cancer.

Skyline Urology experts are involved in research to remain on the cutting edge of new and promising treatment modalities which will help you fight prostate cancer at any stage.

What is Advanced Prostate Cancer?

Metastasis is the medical term for cancer that has spread beyond the origin of the disease. For prostate cancer, metastasis often results in the disease spreading to the bones and lymph nodes. Later on prostate cancer can spread to the liver, or lungs. If prostate cancer is “locally advanced” that indicates that it has spread from the prostate to nearby tissue, but not spread further than the area around the prostate. 

Many men with metastatic prostate cancer go on to live a normal life for many years after diagnosis.

The primary goals of treatment for advanced prostate cancer are to manage the symptoms of the disease, to slow the rate of cancer growth, and in some cases to shrink the tumor.


Prostate cancer at any stage, including advanced of metastatic forms of the disease, may not cause any symptoms in the patient. Often prostate cancer, even in its most advanced form, is discovered when doing routine examinations or during testing and treatment for another condition.

If the prostate is locally advanced, symptoms may include bladder issues such as painful urination or decreased urine stream, blood in semen or urine, general pain in the lower back and hips, and erectile dysfunction.

Metastatic prostate cancer which has spread to lymph nodes or other organs in the body may cause bone pain, swelling of the hands and feet, and weight loss.

If you exhibit these symptoms, or have a risk of prostate cancer due to family history, age, or other factors, please make an appointment at Skyline Urology for the most advanced diagnostic testing available in Southern California.

Risk Factors: 

The most common risk factors for developing advanced prostate cancer include age and a previous family history of the disease. The risk of developing prostate cancer increases annually in men after age 50, and by age 70 studies show that the majority of men may suffer from at least pre-cancerous growth of cells in the prostate. 

One out of every two men who have had a diagnosis of prostate cancer in their lifetime will develop the metastatic form of the disease at some point, which is why continued monitoring of your prostate with your Skyline Urology is important even after the disease has been treated. If you have already had prostate cancer and have been treated, your physician may look for factors such a lymph node involvement and high Gleason score, or measure the size of the tumor, as an indicator of whether you are at greater risk for developing metastatic prostate cancer later in life.

As with most cancers, your family history will impact the likelihood of developing the prostate cancer at any stage – if you have a brother or a father with prostate cancer, your risk for the disease is doubled. Race seems to be a factor as well, with African American males recording the highest levels of prostate cancer in the world.

Like early stage prostate cancer, lifestyle may impact your risk of developing the advanced form of the disease.   Prostate cancer is much more common in countries where meat and high-fat dairy foods are prevalent, but the causation and reason is still unclear. Factors such as smoking and obesity seem to play a role in the likelihood of developing cancer, and that is true for advanced prostate cancer as well.


Prostate cancer at any stage will most likely be first diagnosed as a result of a physical examination, which includes a rectal exam and/or an abnormal blood test. Physical signs of prostate cancer, which could present with or without symptoms, would include enlargement of the organ or a lump on the prostate detected by a physician.

Because of the likelihood of recurrence of prostate cancer in men who have been diagnosed with the disease in the past, if you have a history of prostate cancer – or a family member has had prostate cancer – you should be evaluated more thoroughly beginning at age 40 or above.

Skyline Urology has the most advanced, comprehensive diagnostic tools available in Southern California to find and treat your prostate cancer at any stage. If there is a possibility you may have advanced prostate cancer, Skyline Urology physicians will work closely with you to identify and treat the cancer and its symptoms to stop the further spread of the disease and manage any complications from the cancer or its treatment.

Evaluation options include:

Treatment Options: